For those of you who're unfamiliar with the Nintendo DS (and the more recent DS Lite version), it's a hand-held gaming platform which utilizes two LCD touch-screen displays (the "DS" in the name stands for "dual screen"). In this game, one screen is used for viewing and looking around, plus talking to people. The other screen is to move around (you get a floor map in order to do this effectively). Unlike most gaming systems -- especially hand-held ones -- the DS has a stylus (much like a PDA) which allows you to interact without knowing which buttons to push. The DS does have a D-Pad and some buttons, but many of the games primarily use the stylus. Since the DS can play older Gameboy Advanced games as well, the D-Pad and buttons were added to make gameplay possible (the GBA did not have touch-screen capability).
I have not played Hotel Dusk: Room 215, mostly because I do not own a DS. If you own either a DS or a DS Lite, I'd recommend picking this game up, purely based on reviews, word of mouth, the Wikipedia article and the website.
As a side-note, the game's protagonist is who I'm currently using as my tag (after colorizing it, of course).
