So this has been making the rounds in retro video game circles. It's been used with great effect for Doom sprite and texture upscaling and the Duke3D community has also been experimenting with it. I found a thread that featured upscaled backgrounds from Monkey Island 2 and the results are quite incredible (
here's the thread with even more examples that are simply astounding). There are various models for filters available. One is waifu2x but that one makes things look only slightly better than your standard SuperEagle or hq2x filters. This one called ESRGAN (which uses a data set called Manga109 as a base) however....well, see for yourself.
Upscaled (no, seriously. this is an honest-to-god upscale without any post-editing):
Original:
And for the sake of comparison, here's the official MI2 Special Edition background:
The results are pretty fantastic. Here's another one from MI2:
Imagine seeing a filter like this generated in real-time in programs like ScummVM and DOSBox!